Obsessive-compulsive disorder

Preferred Label : Obsessive-compulsive disorder;

Symbol : OCD;

CISMeF acronym : OCD;

Type : Phenotype, molecular basis known;

Description : Obsessive-compulsive disorder (OCD) is characterized by recurring obsessions and/or compulsions and has been estimated to affect nearly 5 million people in the United States (Karno et al., 1988). Evidence for a strong genetic component in OCD comes from twin studies, family genetics studies, and segregation analyses, as reviewed by Alsobrook et al. (2002). Zhang et al. (2002) suggested that hoarding is likely to be an evolutionarily conserved trait that, in times of adversity, was associated with increased survival and reproductive fitness. However, extreme forms of this trait are associated with marked disability and poor response to treatment (Black et al., 1998; Mataix-Cols et al., 1999).;

Inheritance : Autosomal dominant form;

Prefixed ID : #164230;

Details

Origin ID

164230;

UMLS CUI

C0028768;

Automatic exact mappings (from CISMeF team)
- Obsessive-compulsive disorders [PASCAL theme]
- Obsessive-compulsive disorders [FRANCIS theme]
- Osteochondritis dissecans [ICD-11 More detail]
- Other obsessive-compulsive disorders [ICD-10 Sub-category (who)]
- osteochondritis dissecans [DO Concept]
- phobia/compulsive disorder [ICPC-2 Rubric]
False automatic mappings
- Osteochondritis dissecans (disorder) [SNOMED CT concept]
Genes related to phenotype
- 5-hydroxytryptamine receptor 2a [OMIM gene]
- Solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 [OMIM gene]
HPO term(s)
- Anxiety [HPO term]
- Autosomal dominant inheritance [HPO term]
- Collectionism [HPO term]
- Depression [HPO term]
- Obsessive-compulsive behavior [HPO term]
- Skin-picking [HPO term]
Semantic type(s)
- Mental or Behavioral Dysfunction [UMLS semantic type]
UMLS correspondences (same concept)
- Obsessive Compulsive Disorder [NCIt concept]
- Obsessive-Compulsive disorder [MeSH concept]
- Obsessive-compulsive disorder [ICD-10 category (who)]
- Obsessive-compulsive disorder [MedDRA Preferred Term]
- Obsessive-compulsive disorder [ICD-10 category]
- Obsessive-compulsive disorder (disorder) [SNOMED CT concept]
- Obsessive-compulsive disorder, unspecified [ICD-10 Sub-category]
- Obsessive-compulsive disorders [ICD-9 code]
- Obsessive-compulsive neurosis [MedDRA LLT]
- Obsessive-compulsive reaction [MedDRA LLT]
- Reaction obsessive-compulsive [MedDRA LLT]
- obsessive compulsive disorder, nos [SNOMED Notion]
- obsessive-compulsive disorder [MedlinePlus Topic]
- obsessive-compulsive disorder [MeSH Descriptor]
- obsessive-compulsive disorder [DO Concept]
Validated automatic mappings to BTNT
- obsessive compulsive personality disorder [Disease (Nov.)]

Keyword's position in hierarchy(ies) :

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