Preferred Label : Laryngeal web, familial;
Type : Other, mainly phenotypes with suspected mendelian basis;
Alternative titles and symbols : Glottic web, congenital anterior; Subglottic web; Subglottic bar;
Description : Congenital laryngeal (glottic) webs are uncommon, membrane-like structures that extend
across the laryngeal lumen near the level of the vocal cords. They are thought to
result from incomplete resorption of an epithelial layer that normally obliterates
the developing laryngeal opening at about the sixth week of embryologic life. This
layer is usually completely eliminated by the tenth week. Most laryngeal webs occur
at the glottic level and affect the vocal cords. More than 90% are located anteriorly
and extend toward the arytenoids. While affected persons may have onset of manifestations
at any age, with hoarse or weak voice and frequent upper respiratory infections, they
usually manifest the condition as infants, with respiratory distress, stridor, and
an unusual cry (Strakowski et al., 1988; Singh et al., 2009).;
Inheritance : Autosomal dominant;
Prefixed ID : 150360;
Origin ID : 150360;
UMLS CUI : C1835494;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- HPO term(s)
- ORDO concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
