" /> Kleeblattschaedel - CISMeF





Preferred Label : Kleeblattschaedel;

Type : Other, mainly phenotypes with suspected mendelian basis;

Alternative titles and symbols : KLEEBLATTSCHADEL; Cloverleaf skull;

Description : Cloverleaf skull, or Kleeblattschaedel, consists of a trilobular skull with craniosynostosis. The condition shows pathogenetic variability and etiologic heterogeneity. The cause of isolated cloverleaf skull is unknown (Cohen, 2009). Cohen (1975) pointed out that Kleeblattschaedel is a component of many syndromes, e.g., it is found in some cases of Crouzon syndrome (123500), Pfeiffer syndrome (101600), and Carpenter syndrome (201000). Cohen (2009) listed 12 monogenic disorders with cloverleaf skull as a feature, including type 2 thanatophoric dysplasia (187601), which accounts for 40% of all cloverleaf skull syndromes. Cohen (2009) published photographs of cloverleaf skull in various syndromes.;

Inheritance : Autosomal dominant; all cases have been sporadic;

Prefixed ID : 148800;

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27/07/2025


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