Alternative titles and symbols : Gabrb3; Gaba-a receptor, beta-3 polypeptideinsomnia;
Description : Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the
GABAergic neurotransmission of the mammalian central nervous system. GABRB3 is a member
of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels
through which GABA, the major inhibitory neurotransmitter in the mammalian brain,
acts. GABA-A receptors are the site of action of a number of important pharmacologic
agents including barbiturates, benzodiazepines, and ethanol (summary by Whiting et
al., 1999). For additional general information about the GABA-A receptor gene family,
see GABRA1 (137160).;