" /> Frasier syndrome - CISMeF





Preferred Label : Frasier syndrome;

Type : Phenotype, molecular basis known;

Description : Frasier syndrome is a rare disorder defined by pseudohermaphroditism and progressive glomerulopathy (Frasier et al., 1964; Haning et al., 1985; Kinberg et al., 1987). Patients present with normal female external genitalia, streak gonads, and XY karyotype, and frequently develop gonadoblastoma (Blanchet et al., 1977). Glomerular symptoms consist of childhood proteinuria and nephrotic syndrome, characterized by nonspecific focal and segmental glomerular sclerosis, progressing to end-stage renal failure in adolescence or early adulthood. Wilms tumor is not a usual feature (Barbaux et al., 1997).;

Inheritance : Autosomal dominant; Somatic mutation;

Molecular basis : Caused by mutations in the Wilms tumor 1 gene (WT1, 607102.0018).;

Neoplasia : Gonadoblastoma;

Prefixed ID : #136680;

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01/05/2025


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