Preferred Label : Frasier syndrome;
Type : Phenotype, molecular basis known;
Description : Frasier syndrome is a rare disorder defined by pseudohermaphroditism and progressive
glomerulopathy (Frasier et al., 1964; Haning et al., 1985; Kinberg et al., 1987).
Patients present with normal female external genitalia, streak gonads, and XY karyotype,
and frequently develop gonadoblastoma (Blanchet et al., 1977). Glomerular symptoms
consist of childhood proteinuria and nephrotic syndrome, characterized by nonspecific
focal and segmental glomerular sclerosis, progressing to end-stage renal failure in
adolescence or early adulthood. Wilms tumor is not a usual feature (Barbaux et al.,
1997).;
Inheritance : Autosomal dominant; Somatic mutation;
Molecular basis : Caused by mutations in the Wilms tumor 1 gene (WT1, 607102.0018).;
Neoplasia : Gonadoblastoma;
Prefixed ID : #136680;
Origin ID : 136680;
UMLS CUI : C0950122;
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
DO Cross reference
Genes related to phenotype
HPO term(s)
ORDO concept(s)
Semantic type(s)
UMLS correspondences (same concept)