Preferred Label : Dwarfism, levi type;
Type : Other, mainly phenotypes with suspected mendelian basis;
Alternative titles and symbols : Snub-nosed type of dwarfism;
Description : Levi (1910) described 2 families with 'microsomie essentielle' displaying dominant
inheritance. Body proportions were normal. Levi (1910) pictured (see Black, 1961)
affected father and son. Von Verschuer and Conradi (1938) suggested recessive inheritance.
Black (1961) referred to the disorder as 'snub-nosed' dwarfism, a variety of low-birth-weight
dwarfism, and suggested that both dominant and recessive forms exist. The low birth
weight is, perhaps, not well documented and this condition may in fact be sexual ateliosis
(262400). The phenotypes of the presumed dominant and recessive forms seem identical
and possibly Levi's pedigree was an instance of quasidominance. On the other hand,
cases of primordial dwarfism in successive generations are cited by Warkany et al.
(1961), notably the family studied by Selle (1920) in which 10 persons in 3 generations
were affected. McKusick (1975) saw an isolated case of what appeared to be 'snub-nosed'
dwarfism. The parents pointed out that 'snub-nosed' may not be an acceptable designation
for laymen. McKusick (2002) noted that no recent descriptions of this entity had been
forthcoming. *FIELD* RF 1. Black, J.: Low birth weight dwarfism. Arch. Dis. Child.
36: 633-644, 1961. 2. Levi, E.: Contribution a la connaissance de la microsomie essentielle
heredo-familiale: distinction de cette forme clinique d'avec les nanismes, les infantilismes
et les formes mixtes de ces differentes dystrophies. Nouv. Iconogr. Salpetr. 23: 552-570,
1910. 3. McKusick, V. A.: Personal Communication. Baltimore, Md. 2002. 4. McKusick,
V. A.: Personal Communication. Baltimore, Md. 1975. 5. Selle, G.: Ueber Vererbung
des echten Zwergwuchses. Inaug. Dissert.: Univ. of Jena (pub.) 1920. 6. Von Verschuer,
O. F.; Conradi, L.: Eine Sippe mit rezessiv erblichem primordialem Zwergwuchs. Z.
Menschl. Vererb. Konstitutionsl. 22: 261-267, 1938. 7. Warkany, J.; Monroe, B. B.;
Sutherland, B. S.: Intrauterine growth retardation. Am. J. Dis. Child. 102: 249-279,
1961. *FIELD* CS Autosomal dominant; Autosomal recessive;
Inheritance : Autosomal dominant; Autosomal recessive;
Prefixed ID : 127100;
Origin ID : 127100;
UMLS CUI : C1851994;
Currated CISMeF NLP mapping
- HPO term(s)
- Semantic type(s)
- UMLS correspondences (same concept)
