" /> Coumarin resistance - CISMeF





Preferred Label : Coumarin resistance;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : Coumarin, poor metabolism of; Warfarin resistance;

Included titles and symbols : Coumarin sensitivity; Warfarin sensitivity;

Description : Warfarin is a widely prescribed anticoagulant for the prevention of thromboembolic diseases for subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement (Yuan et al., 2005). The dose requirement is highly variable, both interindividually and interethnically. Variation in the VKORC1 gene is believed to be the most important individual predictor of warfarin dose, accounting for about 30% of the variance observed in dosing (Ross et al., 2010).;

Inheritance : Autosomal dominant;

Molecular basis : Drug sensitivity conferred by mutation in the cytochrome P450, subfamily IIA, polypeptide 6 gene (CYP2A6, 122720.0001); Drug sensitivity conferred by mutation in the cytochrome P450, subfamily IIC, polypeptide 9 gene (CYP2C9, 601130.0001); Drug sensitivity conferred by mutation in the Vitamin K epoxide reductase complex, subunit 1 gene (VKORC1, 608547.0002);

Laboratory abnormalities : Warfarin resistance; Warfarin sensitivity;

Prefixed ID : #122700;

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27/07/2025


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