Preferred Label : Chromate resistance;
Symbol : CHR;
CISMeF acronym : CHR;
Type : Phenotype or locus, molecular basis unknown;
Description : In interspecific human-Chinese hamster ovary (CHO) cell hybrids, Dana and Wasmuth
(1982) showed that resistance to concentrations of sodium chromate that normally are
cytotoxic is determined by a gene on chromosome 5 in man. The biochemical nature of
the mutation that results in chromate resistance is unknown. Emetine resistance (EMTB;
130620) and temperature-sensitive leucyl-tRNA synthetase (LEUS; 151350) are also determined
by genes on human chromosome 5. The synteny of the 3 loci has been long maintained
in evolution, evidenced by the fact that the 3 loci are linked on the long arm of
Chinese hamster chromosome 2. Dana and Wasmuth (1982) subjected Chinese hamster-human
interspecific hybrid cells, which contained human chromosome 5 and expressed the 4
syntenic genes LEUS, HEXB (606873), EMTB, and CHR, to selective conditions requiring
them to retain the LEUS gene but lose either the EMTB or CHR gene. Using cytogenetic
and biochemical analyses of spontaneous segregants, which arose primarily by terminal
deletions of various portions of 5q, Dana and Wasmuth (1982) concluded that the order
and specific locations of the linked genes are: LEUS, 5pter-5q1; HEXB, 5q13;;
Prefixed ID : %118840;
Origin ID : 118840;
UMLS CUI : C1861559;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
