Alopecia, androgenetic, 1

Preferred Label : Alopecia, androgenetic, 1;

Symbol : AGA1;

CISMeF acronym : AGA; AGA1; MPB;

Type : Phenotype or locus, molecular basis unknown;

Alternative titles and symbols : Androgenetic alopecia; AGA;

Included titles and symbols : Baldness, male pattern; MPB;

Description : Androgenetic alopecia is characterized by a loss of hair from the scalp that follows a defined pattern (Hamilton, 1951). It occurs in women as well as in men. It is caused by a shortening of the anagen (growth) phase and miniaturization of the hair follicle, which results in the formation of progressively thinner, shorter hair (Bergfeld, 1995). In men, the condition is often referred to as male pattern baldness (MPB) and appears to be androgen-dependent (Hamilton, 1942). The condition is hereditary, and follows a pattern that may be consistent with an autosomal dominant trait (Osborn, 1916). Linkage evidence for an autosomal locus on 3q26 (AGA1) has been identified (Hillmer et al., 2008). See 300710 (AGA2) for a discussion of X linkage of androgenetic alopecia. A third locus has been found on chromosome 20p11 (AGA3; 612421).;

Inheritance : Autosomal dominant in males; recessive in females;

Prefixed ID : %109200;

Details

Origin ID

109200;

UMLS CUI

C4049090;

Automatic exact mappings (from CISMeF team)
- Male pattern baldness [MedDRA LLT]
- Male pattern hair loss [ICD-11 Subcategory]
DO Cross reference
- androgenic alopecia [DO Concept]
False automatic mappings
- Androgenetic alopecia [MedDRA Preferred Term]
- Gliadin Ab [LOINC component]
- Male pattern alopecia (disorder) [SNOMED CT concept]
- VMP Regimen [NCIt concept]
- androgenetic alopecia [MeSH concept]
- aspartylglucosaminidase [ORDO Gene]
HPO term(s)
- Alopecia [HPO term]
- Sex-limited autosomal dominant [HPO term]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
Validated automatic mappings to NTBT
- Androgenetic alopecia [PASCAL descriptor]
- Frontal balding [HPO term]
- alopecia [MeSH Descriptor]
- androgenic alopecia [DO Concept]
- male type alopecia [Disease (Nov.)]

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