LOINC display name : Abnormal Prion Protein Ql (CSF);
LOINC long common name : Abnormal Prion Protein [Presence] in Cerebral spinal fluid;
LOINC short name : Abn Prion Prot CSF Ql;
LOINC description : Detection of pathologic prions in cerebrospinal fluid (CSF). The submitter's test
uses recombinant prion protein (PrP) as a reagent substrate and patient CSF in a real-time
quaking-induced conversion (RT-QuIC) assay. If pathologic prions are present in the
patient's CSF, they propagate misfolding of the reagent PrP to form amyloid, which
is detected using a fluorescent indicator. RT-QuIC has been adopted in clinical practice
due to the sensitivity, specificity, and use of CSF (not a brain biopsy) for testing.
The submitter's reported sensitivity of RT-QuIC in detecting CJD is 90%, and the
specificity approaches 100%.;
Has component