LOINC display name : ERBB2 gene dup FISH Doc (Tumor);
LOINC long common name : ERBB2 gene duplication in Tumor by FISH;
LOINC short name : ERBB2 gene Dp Tumor FISH;
LOINC description : Gene duplication analysis of the ERBB2 gene by FISH studies is performed to guide
therapy for patients with primary or metastatic breast tumors. Patients with ERBB2
gene amplification leading to overexpression of the human epidermal growth factor
receptor 2 (HER2) protein may be candidates for therapies, such as trastuzumab and
pertuzumab, that target HER2. Testing may also be performed to confirm the presence
of HER2 amplification in cases with 2 (low level) or 3 (high level) HER2 protein
overexpression by immunohistochemistry, as well as for certain histologic subtypes
with aberrant patterns of HER2 expression seen by immunohistochemistry. The collection
of information contained by this term may include the overall result (positive/negative),
copy numbers and ratio of HER2 to CEP17, the interpretation, recommendations, and
references. For associated observations (result codes) related to this test, see the
ERBB2 gene duplication associated observations panel [LOINC: 74885-5].;
Has component