LOINC display name : SARS-CoV-2 (COVID-19) neut ab pVNT (S) [Titer];
LOINC long common name : SARS-CoV-2 (COVID-19) neutralizing antibody [Titer] in Serum by pVNT;
LOINC short name : SARS-CoV-2 NAb Titr Ser pVNT;
LOINC description : Quantitative titer results for SARS Coronavirus 2 (SARS-CoV-2) virus neutralizing
antibodies in serum by pVNT (pseudovirus neutralization test). Neutralizing antibody
testing is performed to determine whether the antibodies produced after SARS-CoV-2
infection or in response to a vaccination are able to neutralize the virus and prevent
infection or re-infection. Different methods can be used to determine the presence
of neutralizing antibodies, including VNT (virus neutralization test) and pVNT, which
are represented in LOINC as the Method Neutralization and pVNT, respectively. The
pVNT method for SARS-CoV-2 neutralizing antibody testing uses recombinant pseudoviruses
that incorporate the S protein from SARS-CoV-2, whereas VNT uses SARS-CoV-2 virus
from a clinical isolate or recombinant SARS-CoV-2 expressing reporter proteins.;