Preferred Label : Tumor mutation burden:Imp:Pt:Tumor:Ord:;
LOINC status : ACTIVE;
LOINC display name : Tumor mutation burden Ql (Tumor) [Interp];
LOINC long common name : Tumor mutation burden [Interpretation];
LOINC short name : TMB Tumor-Imp;
LOINC description : Tumor mutational burden (TMB), also known as mutation load, is a biomarker for various
cancer types to identify patients who will benefit from immunotherapy, such as immune
checkpoint blockade (ICB) therapy. Testing can be performed by whole exome sequencing
(WES) or next-generation sequencing (NGS). Various quantitative and ordinal results
may be reported, so it is important to distinguish the type of results when mapping
to LOINC. Quantitative results typically include the number of mutations detected
per megabase (mut/Mb), often by NGS, in a tumor specimen [LOINC: 94076-7]. The mutations
targeted may include non-synonymous or both synonymous and non-synonymous mutations.
Quantitative TMB results have also been reported as the total number of mutations
detected by whole exome sequencing (WES). We encourage labs to report how results
are determined or calculated in either the structured message format or using another
LOINC. An ordinal TMB result (this term) of high, low, etc., may also be reported
to provide an overall interpretation for the quantitative value (muts/Mb). Cut-offs
vary across assays and for each tumor type, so it is important to know which assay
was used to determine the overall ordinal TMB result.;
Origin ID : 94077-5;
UMLS CUI : C5212652;
Has component
- Has property
- Has scale
- Has system
- Has time aspect
- Semantic type(s)
