LOINC display name : Mutations/Megabase (Tumor) [# ratio];
LOINC long common name : Mutations/Megabase [# Ratio] in Tumor;
LOINC short name : Muts/Mb Tumor;
LOINC description : Tumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker
for various cancer types to identify patients who will benefit from immunotherapy,
such as immune checkpoint blockade (ICB) therapy.[PMID: 30395155] Various quantitative
and ordinal results may be reported, so it is important to distinguish the type of
results when mapping to LOINC. Quantitative results typically include the number of
mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this
term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous
mutations. An ordinal TMB result [LOINC: 94077-5] of high, low, etc., may also be
reported to provide an overall interpretation for the quantitative value (muts/Mb).
We encourage labs to report how results are determined or calculated in either the
structured message format or using another LOINC.;
Has component