Preferred Label : Warfarin response genotype panel:-:Pt:Bld/Tiss:-:Molgen;
LOINC status : ACTIVE;
LOINC display name : Warfarin response genotype panel Molgen (Bld/Tiss);
LOINC long common name : Warfarin response genotype panel - Blood or Tissue by Molecular genetics method;
LOINC short name : Warfarin genotype pnl Bld/T;
LOINC description : This panel contains genotype results for warfarin dosing. As of 2019, CYP2C9, VKORC1,
CYP4F2, and rs12777823 genotypes are used when available to help determine a patient's
initial therapeutic warfarin dose. VKORC1 and CYP2C9 genotypes are the most important
genetic determinants of warfarin dosing. Additionally, a genetic variation in the
CYP4F2 gene, CYP4F2*3, as well as a variant near the CYP2C gene cluster, rs12777823,
have been associated with influencing warfarin therapy.[NCBI Books: NBK84174] This
panel is based on, but not limited in use to, the 2017 Update of the Clinical Pharmacogenetics
Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing,
which provides warfarin dosing recommendations for adults with and without African
ancestry, and also for pediatric patients.[https://cpicpgx.org/content/guideline/publication/warfarin/2017/warfarin.pdf];
Origin ID : 93196-4;
UMLS CUI : C5211632;
Has component
- Has method
- Has system
- Has time aspect
- Panel of LOINC codes
- Semantic type(s)
