LOINC display name : Bound rFVIII/vWf Ag IA (P) [Relative ratio];
LOINC long common name : Coagulation factor VIII.recombinant.bound/von Willebrand factor (vWf) Ag in Plasma
by Immunoassay;
LOINC short name : Fact VIII.recomb.bound/vWF Ag Plas IA;
LOINC description : This test measures the binding activity of von Willebrand factor (vWF) to Factor VIII
as the ratio of the amount of exogenous recombinant Factor VIII bound to vWF in the
patient sample to the amount of vWF in the patient sample. It is used to differentiate
between various bleeding disorders including hemophilia A and type 2N von Willebrand
disease (2N vWD, VWD2N, or Type 2 Normandy). Type 2N vWD is caused by mutations to
the Factor VIII binding site of vWF, which results in reduced binding and faster clearance
of Factor VIII. Patients with type 2N vWD usually have reduced Factor VIII activity
with normal VWF levels. [PMID: 19298374];
Has component