LOINC long common name : Serotonin release 1.0 IU/mL heparin.low molecular weight [Units/volume] in Serum;
LOINC short name : SRA 1.0 IU/mL LMW heparin Ser-aCnc;
LOINC description : The SRA test is a functional assay that measures heparin-dependent platelet activation.
Patient serum is incubated with donor platelets containing radioactive 14C serotonin
and different concentrations of heparin. Antibody present in the patient serum will
bind and activate donor platelets, releasing radiolabeled serotonin from the platelet
granules. A positive SRA is expected to show 20% release of the 14C serotonin when
mixed with patient serum and low-dose heparin. In addition, the high-dose heparin
must reduce the % release obtained with low-dose heparin by at least 50% in order
to demonstrate that the platelet activation is heparin dependent.;
Has component