LOINC display name : SAP and XIAP FC (WBC) [Interp];
LOINC long common name : SAP and XIAP [Interpretation] in Leukocytes by Flow cytometry (FC);
LOINC short name : SAP XIAP WBC FC-Imp;
LOINC description : Analysis of SLAM (signaling lymphocytic activation molecule)-associated protein (SAP)
and X-linked inhibitor of apoptosis protein (XIAP) levels by flow cytometry is performed
as a preliminary screen for X-linked lymphoproliferative (XLP) disease and X-linked
familial hemophagocytic lymphohistiocytosis (HLH). If SAP protein levels are absent
or decreased, XLP is suspected. If XIAP protein levels are absent or decreased, HLH
(aka XLP-2) is suspected. The diagnosis is confirmed by genetic analysis of the associated
genes (SH2D1A gene for XLP, BIRC4 gene for HLH).;
Has component