Preferred Label : Natural killer cell cytotoxicity panel:-:Pt:Bld MC:-:;
LOINC status : ACTIVE;
LOINC display name : NK cell cytotoxicity panel (Bld MC);
LOINC long common name : Natural killer cell cytotoxicity panel - Blood mononuclear cells;
LOINC short name : NK cytotox Pnl Bld MC;
LOINC description : The natural killer (NK) cytotoxicity profile assesses the functionality of natural
killer cells and is used to evaluate patients with various conditions, including recurrent
herpes viral infections, hemophagocytic lymphohistiocytosis, and suspected or known
monogenic defects. The NK cytotoxicity profile is also used for the evaluation of
immune reconstitution post hematopoietic cell transplantation and post immunomodulatory
therapy. Peripheral blood mononuclear cells (PBMCs) are used as the specimen for NK
cytotoxicity assays because the cytotoxicity of the MC population is predominantly
due to NK cells. In the cytotoxicity assay, samples of the patient's mononuclear cells
(called 'effector cells' or E cells') are incubated with labeled target cells ('T
cells') in a series of predetermined ratios, for example, 100:1 E to T, 50:1 E to
T, 25:1 E to T. Cytotoxicity is measured as the amount of label released when the
target cell is destroyed, and the percent cytotoxicity for a given E:T ratio is the
ratio of label released when all of the target cells are destroyed using a cell lysis
detergent as an experimental control. Several features of the cytotoxicity profile
are important, including the maximum cytotoxicity, the relative difference between
the maximum and the minimum, and the change in percent cytotoxicity between sequential
dilutions. Different patterns of these measures may be associated with different disease
processes. Cytotoxicity may also be reported in terms of lytic units [LOINC: 34439-0],
meaning the number of E cells needed to lyse a certain number of target cells.;
Origin ID : 82720-4;
UMLS CUI : C4298463;
Has component
- Has system
- Has time aspect
- Panel of LOINC codes
- Semantic type(s)
