LOINC display name : Thyroid secretory capacity Calculated by SPINA [Moles/Time];
LOINC long common name : Thyroid secretory capacity [Moles/time] in Serum or Plasma by Calculated.SPINA;
LOINC short name : Thyr secr cap SerPl Calc SPINA-sRate;
LOINC description : Thyroid secretory capacity (also called thyroid output or GT) is the maximum secretion
rate of the thyroid gland under stimulated conditions. The structure parameter inference
approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data to estimate
GT under conditions of substrate saturation. One calculation is based on peripheral
TSH, free T4, thyroid binding globulin and thyroid binding prealbumin values, and
an alternate calculation uses peripheral TSH and total T4. GT calculated using the
SPINA approach is also known as SPINA-GT. SPINA-GT may be useful in diagnosing secondary
or tertiary thyroid conditions and has also been shown to be able to clearly differentiate
between euthyroidism and functional thyroid disorders of primary origin. [PMID: 27375554]
Peripheral deiodinase activity by SPINA, called SPINA-GD, is a related result [LOINC:
82367-4].;
Has component