LOINC display name : Peripheral deiodinase activity Calculated by SPINA [Moles/Time];
LOINC long common name : Peripheral deiodinase activity [Moles/time] in Serum or Plasma by Calculated.SPINA;
LOINC short name : Per deiod act SerPl Calc SPINA-sRate;
LOINC description : The sum activity of peripheral deiodinases (GD, also referred to as deiodination capacity
or total deiodinase activity) is the maximum amount of triiodothyronine (T3) produced
per time-unit by deiodinases outside the central nervous system. The structure parameter
inference approach (SPINA) uses Michaelis-Menten functions and pharmakokinetic data
to estimate GD under conditions of substrate saturation. One calculation is based
on peripheral free T3 and free T4 values, and an alternate calculation uses peripheral
total T3 and free T4. GD calculated using the SPINA approach is also known as SPINA-GD.
SPINA-GD may be useful in diagnosing thyroid conditions that are difficult to diagnose
based on traditional thyroid function studies, such as subclinical forms of thyroid
failure, hypothalamic or pituitary dysfunction, and non-thyroidal illness syndrome.
[PMID: 27375554] Thyroid secretory function by SPINA, called SPINA-GT, is a related
result [LOINC: 82368-2].;
Has component