LOINC display name : ZIKV neut ab Neut test Ql (CSF);
LOINC long common name : Zika virus neutralizing antibody [Presence] in Cerebral spinal fluid by Neutralization
test;
LOINC short name : ZIKV NAb CSF Ql Nt;
LOINC description : Qualitative result for Zika virus neutralizing antibodies in CSF. Serological cross-reactivity
is strong between Zika and other flaviviruses, especially Dengue virus. Therefore,
positive EIA or IF assays for Zika virus IgM antibodies are presumptive only and should
be confirmed by a neutralization assay, such as the plaque-reduction neutralization
test (PRNT), which can discriminate between Zika virus and cross-reacting antibodies
in primary flavivirus infections. Recent Zika virus infection is confirmed by stable
high neutralizing antibody titers, seroconversion, or a 4x or greater increases in
neutralizing antibody titer in a patient's appropriately timed acute and convalescent
phase specimens.;