Preferred Label : Cortisol 12H post XXX challenge:SCnc:Pt:Ser/Plas:Qn:;
LOINC status : ACTIVE;
LOINC display name : Cortisol 12 Hr post Unsp challenge [Moles/Vol];
LOINC long common name : Cortisol [Moles/volume] in Serum or Plasma --12 hours post XXX challenge;
LOINC short name : Cortis 12h p chal SerPl-sCnc;
LOINC description : Timed cortisol levels are obtained for adrenocorticotropic hormone challenge tests
to assist in diagnosing adrenocortical insufficiency as found in Cushing's syndrome
and Addison's disease. There are different types of challenges. ACTH (adrenocorticotropic
hormone) stimulation, where cosyntropin (a synthetic form of ACTH) is given, and then
blood is sampled for cortisol levels before the bolus, and at specified times after
the bolus. The ACTH stimulation directly evaluates adrenal gland function and indirectly
evaluates pituitary gland and hypothalamus function. Cortisol levels rise significantly
after administration of cosyntropin if the adrenal glands are functioning normally.
For the CRH (corticotropin-releasing hormone) stimulation, CRH is given and cortisol
and ACTH levels are determined before the injection, at the injection time, and specified
times following injection. The CRH stimulation test is used to distinguish Cushings
disease from conditions where ACTH is secreted ectopically. For the Dexamethasone
suppression (overnight) test (DST), dexamethasone (Decadron) is given and samples
for cortisol levels are collected the following morning. The DST differentiates the
causes of increased cortisol levels. For the Metyrapone (overnight) stimulation challenge,
metyrapone is given with a snack at midnight. Samples for cortisol, 11-deoxycortisol,
and ACTH are collected the following morning. The metyrapone stimulation test distinguishes
corticotropin-dependent causes (pituitary Cushing's disease and ectopic Cushing's
disease) from corticotropin-independent causes (carcinoma of the lung or thyroid)
of increased cortisol levels.;
Origin ID : 77937-1;
UMLS CUI : C4036529;
Has challenge
- Has component
- Has property
- Has system
- Has time aspect
- Semantic type(s)
