LOINC long common name : Influenza virus A H5 RNA [Cycle Threshold #] in Specimen by NAA with probe detection;
LOINC short name : FLUAV H5 RNA Ct Spec Qn NAA probe;
LOINC description : The goose/Guangdong lineage H5 viruses emerged in the late 90s in Asia and subsequently
became the only lineage of viruses known to be highly pathogenic to poultry and sustained
in wild birds. The World Health Organization recognizes these viruses under a unified
H5 clade nomenclature. Viruses from this lineage, specifically clade 2.3.4.4, were
introduced into North American flyways in late 2014 via the Bering Strait into the
Pacific flyway and again in late 2021 into the Atlantic flyway. [PMID:25855748] The
NALHN influenza A molecular assay (matrix 2009) works well for the detection of this
viral clade and is the primary surveillance tool. As a screening tool, the NAHLN H5
assay does not distinguish geographic lineage nor pathotype (LPAI vs HPAI). This clade
specific assay uses real-time reverse transcriptase PCR targeted to clade H5 2.3.4.4.;