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Noninvasive colorectal cancer DNA occult blood screening:Imp:Pt:Stool:Nar: - CISMeF
Noninvasive colorectal cancer DNA occult blood screening:Imp:Pt:Stool:Nar:LOINC code
Preferred Label : Noninvasive colorectal cancer DNA occult blood screening:Imp:Pt:Stool:Nar:;
LOINC status : ACTIVE;
LOINC display name : Noninvasive colorectal cancer DNA and occult blood screening Nar (Stl) [Interp];
LOINC long common name : Noninvasive colorectal cancer DNA and occult blood screening [Interpretation] in Stool
Narrative;
LOINC short name : Noninv colon ca DNA occ bld scrn Stl-Imp;
LOINC description : This term was created for, but is not limited in use to, Exact Sciences' Cologuard
DNA screening test for colorectal cancer. The Cologuard algorithm includes two laboratory
procedures performed on a single stool specimen: 1) detection and quantification of
fecal occult blood using ELISA; and 2) detection of multiple genetic biomarkers (NDRG4
and BMP3 methylation targets, seven KRAS point mutations, and beta actin as a proxy
for the total amount of human DNA in each sample) using magnetic bead based oligonucleotide
hybrid capture to isolate the biomarkers followed by quantitative real-time target
and signal amplification. The occult blood and genetic biomarker results are subsequently
entered into a logistic regression model, and the results from this model are used
to calculate a composite score from which the final binary result (positive, negative)
is determined. [PMID: 24645800];
Has component