LOINC display name : Hepatocyte growth factor receptor Ag Immune stain Ql (Tiss);
LOINC long common name : Hepatocyte growth factor receptor Ag [Presence] in Tissue by Immune stain;
LOINC short name : HGFR Ag Tiss Ql ImStn;
LOINC description : The stain is interpreted as positive if 50% or more of the tumor cells show moderate
to strong (2 , 3 ) membranous staining, indicating MET amplification. MET amplification
(positive) has been seen in approximately 22% of non-small-cell lung cases with acquired
resistance to anti-EGFR inhibitors. Recent Phase II clinical trails (OAM4558g) results
were released at ASCO in 2011 showed that patients who were c-MET positive (2 or
3 ) lived twice as long without disease progression (PFS) when they received MetMAb
therapy in combination with erlotinib versus receiving erlotinib alone.;
Has component