LOINC display name : 6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy FISH Doc (Bld/Tiss);
LOINC long common name : 6p25 and 6q23 and 11q and 8q24 and 9p21 chromosome partial aneuploidy in Blood or
Tissue by FISH;
LOINC short name : 6p25 6q23 11q 8q24 9p21 aneup Bld/T FISH;
LOINC description : Malignant melanoma often exhibits abnormal copy number of certain chromosomal regions.
The assessment of gains and losses in 6p25, 6q23 11q, 8q24 and 9p21 by fluorescent
in situ hybridization (FISH) has been found to be helpful in distinguishing benign
from malignant melanocytic lesions. This term was created for the submitter's assay
which uses three commercially available probes sets: RREB1/D6Z1/MYB/CCND1 (assessing
chromosomes 6 and 11), CDKN2A/D9Z1 (assessing chromosome 9p), and D8Z2/MYC (assessing
chromosome 8q). The chromosomal abnormalities in melanoma can be varied, so the combined
assay has been found to have a better chance to aid in diagnosis. The findings have
some mechanistic implications, with tumor suppressor genes on 9p and oncogene (MYC)
on 8q.;
Has component