Preferred Label : Lupus anticoagulant three screening tests W Reflex panel:-:Pt:PPP:-:Coag;
LOINC status : ACTIVE;
LOINC display name : Lupus anticoagulant three screening tests W Reflex panel Coag (PPP);
LOINC long common name : Lupus anticoagulant aPTT, dRVVT and PT screening panel W Reflex;
LOINC short name : LA aPTT dRVVT PT W Reflex PPP;
LOINC description : The lupus anticoagulant three screen panel is based primarily on the 2009 International
Society of Thrombosis and Haemostasis (ISTH) and 2014 Clinical and Laboratory Standards
Institute (CLSI) guidelines for detecting the presence of lupus anticoagulants (LA),
with some modifications based on information from major laboratories that use three
screening tests (PT, aPTT and dRVVT) as the first step in LA testing. The ISTH guidelines
recommend using dRVVT as the first screening test and aPTT-LA as the second screening
test, followed by reflex to mixing studies with 1:1 Pooled Normal Plasma and confirmatory
testing with excess phospholipid (PL) if either of the screening tests are positive.
The CLSI guidelines permit use of other screening tests in addition to aPTT and dRVVT,
and also recommend changing the order of the tests to screening following by confirmatory
and then mixing. Some major laboratories reflex to thrombin time (TT) and reptilase
assays if any of the three screening tests have an abnormal result, so both of those
tests are included in the panel. Both ISTH and CLSI recommend reporting quantitative
results as the ratio of the patient result to the control result for each of the screening,
mixing and confirmatory tests that are performed. However, they use different parameters
for the control: ISTH recommends calculating the control based on pooled normal plasma
(PNP), while CLSI recommends using the mean of the reference interval provided by
the assay manufacturer. Many labs report either the actual patient result or the actual
patient result and the actual/normal ratio, so we have included both options in the
panel. In addition to the quantitative results, both guidelines recommend reporting
a qualitative interpretation.;
Origin ID : 75881-3;
UMLS CUI : C3870039;
Has component
- Has method
- Has system
- Has time aspect
- Panel of LOINC codes
- Semantic type(s)
