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Blood group antibody:PrThr:Pt:Ser/Plas:Ord:Blood group antibody screen.LISS - CISMeF
Blood group antibody:PrThr:Pt:Ser/Plas:Ord:Blood group antibody screen.LISSLOINC code
Preferred Label : Blood group antibody:PrThr:Pt:Ser/Plas:Ord:Blood group antibody screen.LISS;
LOINC status : ACTIVE;
LOINC display name : Blood group antibody screen LISS Ql;
LOINC long common name : Blood group antibody screen [Presence] in Serum or Plasma by Low ionic strength saline
(LISS);
LOINC short name : Bld gp Ab Scn SerPl Ql LISS;
LOINC description : Antibody screening is used to demonstrate unexpected antibodies (other than ABO) and
is performed on both donors and recipients to help ensure compatibility between recipient
antibodies and donor red cells. Low ionic strength saline (LISS) is a blood banking
potentiating agent that works by decreasing the repelling charges between red cells
(zeta potential), thus packing the reds cells closer together for increased antibody
bridging. This then decreases the incubation time for the sensitization phase in the
antibody screening. A downside to using LISS is that it enhances the expression of
cold antibodies and auto-antibodies that may not be significant. In addition, the
ratio of serum to red cells must be adhered to strictly to maintain the ionic strength
of the mixture. If ionic strength is too high, false negatives may occur, and if it
is too low, false positives due to complement binding may occur.;
Has component