LOINC display name : Coproporphyrin 3/Total porphyrins (Stl) [Molar fraction];
LOINC long common name : Coproporphyrin 3/Porphyrins.total in Stool;
LOINC short name : Copro3 SFr Stl;
LOINC description : Total fecal porphyrins are markedly increased especially in active HCP (Hereditary
Coproporphyria) and VP (Variegate Porphyria) and to a lesser extent in PCT (Porphyria
Cutanea Tarda) and EPP (Erythropoietic Protoporphyria). Fecal porphyrins can be separated
and measured individually by HPLC. Porphyrins with 2-4 carboxyl groups generally predominate
in feces. These are excreted by the liver into the bile and then flow into the intestine.
As with urine, it is most useful to measure the total amount of porphyrins in a fecal
sample. If this is increased, then the laboratory should determine which porphyrins
predominate rather than focus on the amount of each porphyrin. Fecal porphyrin determinations
may be confounded by variations in fecal flow; most people have one or a few bowel
movements daily and a 24 hour stool collection is really not uniform from day to day.
Substances in the diet and any internal bleeding into the stomach or intestines may
also interfere.;
Has component