" /> ERBB2 gene copy number/nucleus:EntNum:Pt:Tiss:Qn:FISH - CISMeF





Preferred Label : ERBB2 gene copy number/nucleus:EntNum:Pt:Tiss:Qn:FISH;

LOINC status : ACTIVE;

LOINC display name : ERBB2 copy number/nucleus FISH (Tiss) [Entitic number];

LOINC long common name : ERBB2 gene copy number/nucleus in Tissue by FISH;

LOINC short name : ERBB2 copy num/nucleus EntNum Tiss FISH;

LOINC description : The average number of fluorescent signals targeting the ERBB2 gene (HER2 locus) in nuclei are determined in order to calculate the average ratio of ERBB2 gene to Chromosome 17 copy number [LOINC: 49683-6]. This term is based on, but not limited in use to, the PathVysion HER-2 DNA Probe Kit, which detects amplification of the ERBB2 gene via fluorescence in situ hybridization (FISH) in formalin-fixed, paraffin-embedded human breast and gastric cancer tissue specimens. The kit contains two probes: one specific to the HER-2/neu gene locus (ERBB2 gene, 17q11.2-q12) and another targeting the alpha satellite DNA sequence at the centromeric region of chromosome 17 (17p11.1-q11.1), called CEP17 (Chromosome Enumeration Probe 17). The average number of HER2 signals along with CEP17 signals [LOINC: 74861-6] are determined by microscopic examination within the same set of nuclei. The specimen is positive for ERBB2 gene amplification if the mean ratio of HER2 to CEP17 signals per nucleus is greater than or equal to 2.00.;

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28/04/2025


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