LOINC display name : Cortisol/Cortisone [Mass ratio];
LOINC long common name : Cortisol/Cortisone [Mass Ratio] in Serum or Plasma;
LOINC short name : Cortis/Cortisone SerPl;
LOINC description : Apparent mineralocorticoid excess is a rare recessive genetic disease that is characterized
by childhood onset of hypertension, hypokalemic alkalosis, and low plasma renin and
aldosterone level. Hypertension is due to impaired conversion of cortisol to cortisone
due to an inactive 11β-hydroxysteroid dehydrogenase. This condition may be diagnosed
with elevated cortisol metabolite to cortisone metabolite ratios in urine or serum.
It is recommended that cortisol/cortisone ratios (F/E) be tested in hypokalemic hypertension
cases where aldosterone, deoxycorticosterone, and renin are all low. Elevated cortisol/cortisone
ratios may be found in chronic renal failure, or excessive ingestion of glycyrrhetinic
acid or derivatives, or in liver or bile-acid abnormalities.;
Has component