Preferred Label : t(15;17)(q24.1;q21.1)(PML,RARA) bcr3 fusion transcript/control transcript:NRto:Pt:Bld/Tiss:Qn:Molgen;
LOINC status : ACTIVE;
LOINC display name : t(15;17)(q24.1;q21.1)(PML,RARA) bcr3 fusion transcript/control transcript Molgen (Bld/Tiss)
[# ratio];
LOINC long common name : t(15;17)(q24.1;q21.1)(PML,RARA) bcr3 fusion transcript/control transcript [# Ratio]
in Blood or Tissue by Molecular genetics method;
LOINC short name : t(15;17) BCR3/control Bld/T;
LOINC description : A balanced reciprocal translocation involving chromosomes 15 and 17, (15;17)(q22;q21),
results in a fused transcript between PML and RARA genes. This gene fusion produces
the PML-RARA fusion protein, a transcriptional repressor, which causes acute promyelocytic
Leukemia (APL). Depending on the breakpoint within the PML gene, various fusion transcripts
will be generated: long (L or bcr1), variant (V or bcr2), and short (S or bcr3). Techniques
like real-time PCR are used to detect the PML-RARA fused transcripts and breakpoints.
An endogenous control gene transcript (e.g. ABL1, GUS or BCR) is amplified along with
the fusion transcript of interest. Standard curves of known amounts of both the control
and fusion transcript are used to calculate the ratio of the fusion transcript signal
to the control gene signal.;
Origin ID : 72214-0;
UMLS CUI : C3533811;
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