LOINC display name : Cortisol Free/Cortisone free (U) [Molar ratio];
LOINC long common name : Cortisol Free/Cortisone free [Molar ratio] in Urine;
LOINC short name : Cortis F/Cortisone Free Ur-sRto;
LOINC description : Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating
patients with apparent mineralocorticoid excess (AME) syndrome and other forms of
adrenal insufficiency. Higher ratios ( 0.5) are observed in patients with AME syndrome
and indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta
HSD2), which converts cortisol to cortisone. Lower ratios ( 0.15) suggests low activity
of the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain
reduced effectiveness of cortisone treatment.;
Has component