LOINC long common name : PhenX - oral glucose tolerance test protocol 141001;
LOINC short name : Oral glucose tolerance test proto;
LOINC description : Participants are asked to fast for at least 9 hours (generally overnight) prior to
the Oral Glucose Tolerance test. Participants are asked a series of exclusionary questions
and then have an initial blood draw to determine Fasting Plasma Glucose levels. Participants
are next asked to drink a calibrated dose (generally 75 grams / 10 ounces) of a dextrose
solution (e.g., Trutol ) and have a second venipuncture 2 hours (plus or minus 15
minutes) after the first venipuncture. The plasma is separated from the blood via
centrifugation and glucose concentration is determined via the hexokinase method.
The Oral Glucose Tolerance Test includes a Fasting Plasma Glucose assay as the first
step. Therefore performing the Oral Glucose Tolerance Test and the Fasting Plasma
Glucose Assay for Diabetes Screening together will result collecting in the Fasting
Plasma Glucose Assay twice. The Diabetes Working Group notes that an alternative to
the single two-hour post load value is to establish a catheter and obtain samples
for Serum Glucose concentrations at 0, 30, 60, 90 and 120 minutes. There are also
protocols for more rapid sampling of Serum Glucose concentrations. In addition, the
Diabetes Working Group notes that there are also protocols to collect samples for
Serum Insulin concentrations at 0, 30, 60, 90 and 120 minutes and that this could
be done at the same time as the Oral Glucose Tolerance Test. Such protocols would
give extra specificity and information but would increase the burden on both the participant
and investigator.;