LOINC long common name : PhenX - fasting serum insulin protocol 141301;
LOINC short name : Fasting serum insulin proto;
LOINC description : This protocol provides instructions for drawing, processing and storing blood according
to the National Health and Nutrition Examination Survey (NHANES) methods. As there
are no standard assays for insulin, the protocol also provides basic guidelines to
aid comparability among different studies. Although all three are valuable standalone
measures and all should be collected if resources are available, the Diabetes Working
Group recommends that investigators prioritize Insulin 1st, C-peptide 2nd and Proinsulin
3rd. This is because results from the Insulin bioassay can be combined with results
from Fasting Plasma Glucose bioassay to derive the homeostatic model assessment (HOMA)
of insulin resistance and pancreatic beta cell function. The Diabetes Working Group
notes that while it is not the preferred method, the Serum Insulin Assay can be performed
on individuals who have not met the fasting requirements. The Diabetes Working Group
notes that there are also protocols to collect samples for Serum Insulin concentrations
at 0, 30, 60, 90 and 120 minutes and that this could be done at the same time as the
Oral Glucose Tolerance Test. Such protocols would give extra specificity and information
but would increase the burden on both the participant and investigator.;
Has component