LOINC long common name : CD55 CD59 deficient RBC actual/normal in Blood;
LOINC short name : CD55 CD59 def RBC Act/Nor Bld;
LOINC description : Glycophosphatidylinositol(GPI)-linked membrane proteins CD55 (DAF-Decay Acclerating
Factor) and CD59 (Membrane Inhibitor of Reactive Lysis-MIRL) are normally present
on red blood cells to protect the cells from destruction by complement in the immune
system. The expression of CD55 and CD59 is deficient in a subpopulation of patients
with paroxysmal nocturnal hemoglobinuria(PNH). PNH is a disorder is which the stem
cells lack proteins tht prevent them from being destroyed by the body, resulting in
intermittant destruction of cells, usually at night. PNH is characterized by chronic
intravascular hemolysis, bone marrow failure and life threatening thrombosis. Information
from ARUP Laboratories and www.pnhfoundation.org, accessed 2008 01 18.;
Has component