LOINC display name : Glutamate decarboxylase 65 Ab (CSF) [Moles/Vol];
LOINC long common name : Glutamate decarboxylase 65 Ab [Moles/volume] in Cerebral spinal fluid;
LOINC short name : GAD65 Ab CSF-sCnc;
LOINC description : Glutamic acid decarboxylase (GAD65) is an enzyme that is produced primarily by pancreatic
islet cells. Glutamic Acid Decarboxylase antibodies are present in the majority of
individuals with new-onset diabetes and in individuals in the prediabetic phase of
the disease. It appears early in the disease process prior to clinical symptoms and
can be used to predict who will develop IDDM (insulin-dependent diabetes mellitus).
Measurement of GAD65 antibody can be of use in distinguishing insulin-dependent from
non-insulin dependent diabetics when the clinical history is ambiguous. GAD65 autoantibodies
are often markedly elevated in patients with the stiff-person syndrome (also known
as stiff-man syndrome), a condition that is associated with fluctuating stiffness
and paroxysmal spasms of the trunk and legs. Information from http:www.labcorp.com
(Laboratory Corporation of America), accessed 2008 02 13.;
Has component