LOINC display name : Cortisol Free/Cortisone free (U) [Mass ratio];
LOINC long common name : Cortisol Free/Cortisone free [Mass Ratio] in Urine;
LOINC short name : Cortis F/Cortisone Free Ur;
LOINC description : Determining the ratio of urinary-free cortisol to cortisone is useful in evaluating
patients with apparent mineralocorticoid excess (AME) syndrome and other forms of
adrenal insufficiency. Higher ratios are observed in patients with AME syndrome and
indicate insufficient levels of 11-beta-hydroxy steroid dehydrogenase type 2 (11-beta
HSD2), which converts cortisol to cortisone. Lower ratios suggests low activity of
the 11-beta-HSD1 enzyme, which converts cortisone to cortisol, and may explain reduced
effectiveness of cortisone treatment.;
Has component