LOINC display name : Platelet aggregation ADP induced Qn (PRP);
LOINC long common name : Platelet aggregation ADP induced [Units/volume] in Platelet rich plasma;
LOINC short name : PA ADP PRP-aCnc;
LOINC description : Assay is used to measure platelet P2Y12 receptor blockade known to occur with some
drugs including the thienopyridine class of drugs, including clopidogrel (Plavis(r)).
VerifyNow P2Y12 Assay from Accumetrics uses adenosine-5-diphosphate(ADP/PGE1) to induce
platelet activation. Activated platelets bind fibrinogen in proportion to the number
of expressed platelet GPIIb/IIIa receptors. Light transmittance increases as activated
platelets bind and aggregate the fibrinogen-coated beads. A turbidimetric based optical
detection system measures change in optical signal caused by aggregation and reports
results in P2Y12 Reaction Units(PRU). Information from VerifyNow P2Y12 Assay package
insert from Accumetrics dated 2006 09 01;
Has component