LOINC display name : Abnormal Prion Protein RT-QuIC Ql (CSF);
LOINC long common name : Abnormal Prion Protein [Presence] in Cerebral spinal fluid by RT-QuIC;
LOINC short name : Abn Prion Prot CSF Ql RT-QuIC;
LOINC description : Detection of pathologic prions in cerebrospinal fluid (CSF). The test uses recombinant
prion protein (PrP) as a reagent substrate and patient CSF in a real-time quaking-induced
conversion (RT-QuIC) assay. If pathologic prions are present in the patient's CSF,
they propagate misfolding of the reagent PrP to form amyloid, which is detected using
a fluorescent indicator. RT-QuIC has been adopted in clinical practice due to the
sensitivity, specificity, and use of CSF (not a brain biopsy) for testing. The reported
sensitivity of RT-QuIC in detecting CJD is 90%, and the specificity approaches 100%.;
Has component