Preferred Label : NIH shift;
IUPAC acronym : NIH;
IUPAC definition : The intramolecular hydrogen migration which can be observed in enzymatic and chemical
hydroxylations of aromatic rings. It is evidenced by appropriate deuterium labelling,
i.e. In enzymatic reactions the NIH shift is generally thought to derive from the
rearrangement of arene oxide intermediates, but other pathways have been suggested.
(NIH stands for U.S. National Institutes of Health where the shift was discovered.);
Origin ID : N04142;
Automatic exact mappings (from CISMeF team)
- See also
The intramolecular hydrogen migration which can be observed in enzymatic and chemical
hydroxylations of aromatic rings. It is evidenced by appropriate deuterium labelling,
i.e. In enzymatic reactions the NIH shift is generally thought to derive from the
rearrangement of arene oxide intermediates, but other pathways have been suggested.
(NIH stands for U.S. National Institutes of Health where the shift was discovered.)
