IUPAC definition : High dose used in chronic toxicity testing that is expected on the basis of an adequate
subchronic study to produce limited toxicity when administered for the duration of
the test period. It should not induce: (a) overt toxicity, for example appreciable
death of cells or organ dysfunction, or (b) toxic manifestations that are predicted
materially to reduce the life span of the animals except as the result of neoplastic
development or (c) 10% or greater retardation of body weight gain as compared with
control animals. In some studies, toxicity that could interfere with a carcinogenic
effect is specifically excluded from consideration.;
High dose used in chronic toxicity testing that is expected on the basis of an adequate
subchronic study to produce limited toxicity when administered for the duration of
the test period. It should not induce: (a) overt toxicity, for example appreciable
death of cells or organ dysfunction, or (b) toxic manifestations that are predicted
materially to reduce the life span of the animals except as the result of neoplastic
development or (c) 10% or greater retardation of body weight gain as compared with
control animals. In some studies, toxicity that could interfere with a carcinogenic
effect is specifically excluded from consideration.