Preferred Label : dose-response and dose-effect relationships;
IUPAC definition : The graph of the relation between dose and the proportion of individuals responding
with an all-or-none effect; it is essentially the graph of the probability of an occurrence
(or the proportion of a population exhibiting an effect) against dose. Typical examples
of such all-or-none effects are mortality or the incidence of cancer. The dose-effect
curve is the graph of the relation between dose and the magnitude of the biological
change produced measured in appropriate units. It applies to measurable changes giving
a graded response to increasing doses of a drug or xenobiotic. It represents the effect
on an individual animal or person, when biological variation is taken into account.
An example is the increased effect of lead on the haem synthesis, i e.g. /i , on
activity of the enzyme 6-amino laevulinic acid dehydratase in blood serum or coproporphyrin
levels in urine.;
Origin ID : DT06906;
See also
The graph of the relation between dose and the proportion of individuals responding
with an all-or-none effect; it is essentially the graph of the probability of an occurrence
(or the proportion of a population exhibiting an effect) against dose. Typical examples
of such all-or-none effects are mortality or the incidence of cancer. The dose-effect
curve is the graph of the relation between dose and the magnitude of the biological
change produced measured in appropriate units. It applies to measurable changes giving
a graded response to increasing doses of a drug or xenobiotic. It represents the effect
on an individual animal or person, when biological variation is taken into account.
An example is the increased effect of lead on the haem synthesis, i e.g. /i , on
activity of the enzyme 6-amino laevulinic acid dehydratase in blood serum or coproporphyrin
levels in urine.
