Preferred Label : Mocravimod;
NCIt synonyms : 1,3-Propanediol, 2-amino-2-(2-(2-chloro-4-((3-(phenylmethoxy)phenyl)thio)phenyl)ethyl)-; KRP-203 Free Base; 2-Amino-2-(2-(2-chloro-4-(3-benzyloxyphenylthio)phenyl)ethyl)-1,3-propanediol;
NCIt definition : A sphingosine 1-phosphate (S1P) receptor agonist, with potential immunosuppressive
activity. Upon administration of mocravimod, this agent binds to S1P receptors on
lymphocytes, which prevents binding of serum S1P to S1P receptors and leads to S1P
receptor internalization. This reduces the number of circulating blood leukocytes
and accelerates lymphocyte homing into peripheral lymph nodes, thereby preventing
their infiltration into peripheral inflammatory sites. This agent also decreases the
production of inflammatory cytokines by lymphocytes, such as interferon gamma (IFN-g),
interleukin-12 (IL-12), and tumor necrosis factor (TNF).;
UNII : X71GCJ0HLI;
InChIKey : IINUNQPYJGJCJI-UHFFFAOYSA-N;
CAS number : 509092-16-4;
NCI Metathesaurus CUI : CL1382678;
Origin ID : C170189;
UMLS CUI : C5418463;
Semantic type(s)
- concept_is_in_subset
