ICD-11 code : 1F27.10;
Preferred Label : Meningitis due to Cryptococcus neoformans;
ICD-11 definition : Inflammation of the pia and arachnoid and spinal fluid associated with the fungus
cryptococcus neoformans. The respiratory tract is the usual portal of entry and meningitis
may occur after dissemination to the meninges from the lungs. C. neoformans meningitis
tends to occur in patients with defective cellular immunity. The meningitis usually
evolves subacutely, but may be acute. Clinical features include headache, fever, nausea
and vomiting, meningismus, visual disturbances, abnormal mental status, seizures,
and raised intracranial pressure. Headache, fever, and stiff neck may be absent. The
diagnosis is made by microscopic examination of the spinal fluid, culture of CSF and
blood, and the latex agglutination test to detect the capsular polysaccharide antigen
in CSF and blood. The organism may be seen on Gram stain or India ink stain of the
CSF. The spinal fluid usually shows varuable lymphocytic pleocytosis, a low glucose
content, and a high protein level.;
ICD-11 synonym : cryptococcus meningitis; Cryptococcal meningitis; Fungal meningitis due to Cryptococcus neoformans; meningitis due to cryptococcus; cryptococcosis meningitis; Cryptococcal meningoencephalitis;
Origin ID : 738912364;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
Inflammation of the pia and arachnoid and spinal fluid associated with the fungus
cryptococcus neoformans. The respiratory tract is the usual portal of entry and meningitis
may occur after dissemination to the meninges from the lungs. C. neoformans meningitis
tends to occur in patients with defective cellular immunity. The meningitis usually
evolves subacutely, but may be acute. Clinical features include headache, fever, nausea
and vomiting, meningismus, visual disturbances, abnormal mental status, seizures,
and raised intracranial pressure. Headache, fever, and stiff neck may be absent. The
diagnosis is made by microscopic examination of the spinal fluid, culture of CSF and
blood, and the latex agglutination test to detect the capsular polysaccharide antigen
in CSF and blood. The organism may be seen on Gram stain or India ink stain of the
CSF. The spinal fluid usually shows varuable lymphocytic pleocytosis, a low glucose
content, and a high protein level.
