ICD-11 definition : This phenomenon, also named downgrading reaction, occurs in borderline leprosy states
and is associated with a decrease in cell-mediated immunity with a shift towards the
lepromatous end of the clinical spectrum.;
This phenomenon, also named downgrading reaction, occurs in borderline leprosy states
and is associated with a decrease in cell-mediated immunity with a shift towards the
lepromatous end of the clinical spectrum.