ICD-11 code : BC43.7;
Preferred Label : Diabetic cardiomyopathy;
ICD-11 definition : Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of
overt clinical coronary artery disease, valvar disease, and other conventional cardiovascular
risk factors, such as hypertension and dyslipidemia. It is initially characterised
by myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, progressing
to systolic dysfunction and heart failure. Additional information. The development
and progression of diabetic cardiomyopathy has been linked to impaired cardiac insulin
metabolic signaling, increases in oxidative stress, reduced nitric oxide bioavailability,
collagen-based cardiomyocyte and extracellular matrix stiffness, impaired mitochondrial
and cardiomyocyte calcium handling, inflammation, renin–angiotensin–aldosterone system
activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular
dysfunction, and a myriad of cardiac metabolic abnormalities.;
Origin ID : 848543944;
Automatic exact mappings (from CISMeF team)
Diabetic cardiomyopathy is the presence of myocardial dysfunction in the absence of
overt clinical coronary artery disease, valvar disease, and other conventional cardiovascular
risk factors, such as hypertension and dyslipidemia. It is initially characterised
by myocardial fibrosis, dysfunctional remodeling, and diastolic dysfunction, progressing
to systolic dysfunction and heart failure. Additional information. The development
and progression of diabetic cardiomyopathy has been linked to impaired cardiac insulin
metabolic signaling, increases in oxidative stress, reduced nitric oxide bioavailability,
collagen-based cardiomyocyte and extracellular matrix stiffness, impaired mitochondrial
and cardiomyocyte calcium handling, inflammation, renin–angiotensin–aldosterone system
activation, cardiac autonomic neuropathy, endoplasmic reticulum stress, microvascular
dysfunction, and a myriad of cardiac metabolic abnormalities.
