" /> Premature ovarian failure - CISMeF





ICD-11 code : GA30.6;

Preferred Label : Premature ovarian failure;

ICD-11 definition : Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conceiving and delivering a pregnancy. POF/POI occurs mostly without a known cause, but can be caused by the following conditions: numerical and structural chromosomal abnormalities, Fragile X (FMR1) premutations, autoimmune disorders, radiation therapy, chemotherapy, galactosemia, and other rare enzyme defects or mutations. To be subdivided in 4 categories according to cause: congenital, acquired, iatrogenic and unknown;

ICD-11 synonym : premature ovarian insufficiency; primary ovarian failure NOS; hypergonadotrophic ovarian failure; female hypergonadotropic hypogonadism; primary ovarian insufficiency; primary female hypogonadism; POF - [premature ovarian failure];

ICD-11 acronym : POF;

ICD-11 inclusion : insufficiency of ovary; hypofunction of ovary; ovarian failure; female hypogonadism syndrome; ovarian hypogonadism; ovary secretion deficiency; ovary hyposecretion; premature menopause NOS; decreased oestrogen; ovarian secretion suppression;

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Menopause occurring spontaneously before 40 years of age, generally resulting in secondary amenorrhea although some women may exhibit intermittent ovarian function and ovulation, with a minority conceiving and delivering a pregnancy. POF/POI occurs mostly without a known cause, but can be caused by the following conditions: numerical and structural chromosomal abnormalities, Fragile X (FMR1) premutations, autoimmune disorders, radiation therapy, chemotherapy, galactosemia, and other rare enzyme defects or mutations. To be subdivided in 4 categories according to cause: congenital, acquired, iatrogenic and unknown

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03/05/2025


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