ICD-11 code : 1D60.1;
Preferred Label : Marburg disease;
ICD-11 definition : A severe disease with high case fatality caused by infection with Marburg virus or
a closely related virus. Marburg disease is typically characterized by acute onset
of fever with non-specific symptoms/signs (e.g., abdominal pain, anorexia, fatigue,
malaise, myalgia, sore throat) usually followed several days later by nausea, vomiting,
diarrhea, and occasionally a variable rash. Severe illness may include hemorrhagic
manifestations (e.g., bleeding from puncture sites, ecchymoses, petechiae, visceral
effusions), encephalopathy, shock/hypotension, multi-organ failure. Common laboratory
findings include thrombocytopenia, elevated transaminase concentrations, electrolyte
abnormalities, and signs of renal dysfunction. Individuals who recover may experience
prolonged sequelae (e.g., arthralgia, neurocognitive dysfunction, uveitis), and clinical
and subclinical persistent infection may occur in immune-privileged compartments (e.g.,
CNS, eyes, testes). Person-to-person transmission occurs by direct contact with blood,
other bodily fluids, organs, or contaminated surfaces and materials with risk beginning
at the onset of clinical signs and increasing with disease severity. Family members,
sexual contacts, healthcare providers, and participants in burial ceremonies with
direct contact with the deceased are at particular risk. The incubation period typically
is 7–11 days (range 2–21 days).;
ICD-11 synonym : green monkey disease; vervet monkey disease; MARD - [Marburg disease];
ICD-11 acronym : MARD;
ICD-11 "other" category code : 1D60.1Y;
ICD-11 "unspecified" category code : 1D60.1Z;
Origin ID : 696598707;
UMLS CUI : C0024788;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- ICD-10 Mapping
- Semantic type(s)
- UMLS correspondences (same concept)
A severe disease with high case fatality caused by infection with Marburg virus or
a closely related virus. Marburg disease is typically characterized by acute onset
of fever with non-specific symptoms/signs (e.g., abdominal pain, anorexia, fatigue,
malaise, myalgia, sore throat) usually followed several days later by nausea, vomiting,
diarrhea, and occasionally a variable rash. Severe illness may include hemorrhagic
manifestations (e.g., bleeding from puncture sites, ecchymoses, petechiae, visceral
effusions), encephalopathy, shock/hypotension, multi-organ failure. Common laboratory
findings include thrombocytopenia, elevated transaminase concentrations, electrolyte
abnormalities, and signs of renal dysfunction. Individuals who recover may experience
prolonged sequelae (e.g., arthralgia, neurocognitive dysfunction, uveitis), and clinical
and subclinical persistent infection may occur in immune-privileged compartments (e.g.,
CNS, eyes, testes). Person-to-person transmission occurs by direct contact with blood,
other bodily fluids, organs, or contaminated surfaces and materials with risk beginning
at the onset of clinical signs and increasing with disease severity. Family members,
sexual contacts, healthcare providers, and participants in burial ceremonies with
direct contact with the deceased are at particular risk. The incubation period typically
is 7–11 days (range 2–21 days).
